I haven't been "medicated" in quite a while, but playing video games and getting toasted used to be one of my favorite pass times. Usually I loved to play any Super Nintendo game, but particularly ones from my childhood. The combination of being baked and playing my childhood favorites amplified that feeling of cozy nostalgia.
Usually I'd like to pop in games like Super Mario World, Mega Man X, A Link to the Past, and Street Fighter II: Turbo. Sometimes Gradius III but that game is way too difficult when medicated, cause it's so fast paced.
Stardew Valley is a good recent edition, since it's such a chill and "feel good" game even when you're sober.