Most Annoying Video Game Character

Yeah, he was a bullshit character, hehehehe, he was even more annoying on the cartoon. Super Mario Bros Super Show I think was the name. Toad's voice is pesky as hell too.
 
Some of my top choices have already been mentioned, so I'll go with Natalia from Goldeneye. I find that escort missions are pretty much always a pain - look at Ashley from RE 4 for a solid example of an irritating character - but Natalia was a special kind of stupid. I can't imagine the number of times she just wandered into a firefight and got herself killed.
 
Yeah, he was a bullshit character, hehehehe, he was even more annoying on the cartoon. Super Mario Bros Super Show I think was the name. Toad's voice is pesky as hell too.

Well, to be fair: everyone had a bit of a grating voice in the animated portions of the The Super Mario Bros Super Show!

(Then again, on that score The Super Mario Bros Super Show pales in comparison to Captain N: The Game Master! Oh, what that show did to the characters from NES games! Most egregiously Mega Man, Simon Belmont, and Mother Brain! Imagine if those characters had their Captain N voices and mannerisms in their respective franchise's more recent games! It would totally kill the mood!)
 
Some of my top choices have already been mentioned, so I'll go with Natalia from Goldeneye. I find that escort missions are pretty much always a pain - look at Ashley from RE 4 for a solid example of an irritating character - but Natalia was a special kind of stupid. I can't imagine the number of times she just wandered into a firefight and got herself killed.

It sounds like you'll really appreciate Cracked's take on video game escort missions then! ;)

 
My vote is for Slippy in Star Fox. He was so annoying! He always seemed to be in trouble and his voice just grated my nerves.

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Leonard from White Knight Chronicles. His incessant whining about a girl he doesn't even know was so damn annoying. The character was so vapid it was ridiculous.